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Health Education & Behavior
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Will Genetic Testing for Complex Diseases Increase Motivation to Quit Smoking? Anticipated Reactions in a Survey of Smokers

Saskia C. Sanderson, PhD

Cancer Research U.K. Health Behaviour Unit, Department of Epidemiology and Public Health, University College London, London

Jane Wardle, PhD

Cancer Research U.K. Health Behaviour Unit, Department of Epidemiology and Public Health, University College London, London

The aim of this study was to improve understanding of smokers’ potential reactions to genetic testing for smoking-related diseases. One thousand twenty-four respondents completed a postal survey; 186were smokers. Questions addressed anticipated psychological and behavioral reactions to genetic test results using hypothetical scenarios. Of smokers, 65% anticipated being motivated to quit smoking upon receiving a positive genetic test result; 39% anticipated being demotivated by a negative result. More smokers anticipated being depressed in response to receiving a positive result for cancer than for heart disease (40% vs. 24%). Anticipated motivation was associated with higher desire to quit and lower nicotine addiction, anticipated depression with poorer understanding of genetic testing, and anticipated demotivation with lower education. Smokers who have a high desire to quit may use genetic testing as a motivational tool. Understanding of genetics may be important in determining how individuals respond to genetic tests for complex diseases.

Key Words: genetic testing • complex diseases • clinical utility • smoking

Health Education & Behavior, Vol. 32, No. 5, 640-653 (2005)
DOI: 10.1177/1090198105278756


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